Excitotoxicity is defined as excessive exposure to glutamate, the main excitatory neurotransmitter in the mammalian CNS. Excitotoxicity has been implicated as a mechanism of brain damage associated with:
- and neurodegenerative disorders such as Alzheimer’s disease, Parkinson’s disease, Huntington’s disease and others
Under normal conditions, glutamate released from the presynaptic neuron activates ionotropic glutamate receptors present on the postsynaptic neuron. This results in the influx of Na+ and Ca2+ ions into the cell, leading to membrane depolarization and generation of action potentials. Overstimulation of glutamate receptors, especially the NMDA subtype, are known to result in neuronal injury and death.
SynAging is offering an in vitro assay inducing neuronal damage and death by glutamate (or NMDA) overstimulation.
This enables the investigation of client’s active substances to prevent or revert excitotoxicity.